Firearm violence occurred more frequently in US cities in 2020 compared with previous years. Two major events of 2020 may explain this increase– enactment of containment policies to reduce the spread of COVID-19 and a national reckoning with systemic racism, including widespread protests sparked by the police killing of George Floyd. This study evaluated independent associations between COVID-19 containment policies and the killing of George Floyd on firearm violence in 1 US city, Philadelphia, Pennsylvania.